782-D Systemic delivery of novel, allosteric STING agonist CRD3874-SI leads to robust anti-cancer activity by generating pro-inflammatory Type I IFN signals while blocking proton channel mediated toxicity

Abstract

BackgroundSTING activates Type1 interferon and pro-inflammatory responses to drive anti-tumor immunity. Current STING agonists under clinical investigation show limited efficacy due to safety considerations that prevent systemic administration. CRD3874-SI, a...