Abstract
Previous work in our lab demonstrated that post-pneumonectomy compensatory lung growth (PPCLG) is an endothelial progenitor cell(EPC)dependent process. MMP-9-/-mice have a defect in mobilization of EPCs and a defect in PPCLG. Restoring EPC mobilization in these mice using stem cell factor(SCF) administration corrects the defect in lung growth. Similar results are seen when the mice are directly injected with exogenously isolated EPCs. Angiopoietin-1(Ang-1) is a potent stimulus to EPC mobilization. We hypothesized that adenoviral gene transfer of Ang-1 to the MMP-9-/-mice might bypass the mobilization defect, increase the mobilization of EPCs, and correct the defect in compensatory lung growth.
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