781-3 Do Racial Differences Effect the Indices of Target Organ Damage in Arterial Hypertension?

Abstract

Differences between blacks and whites have been reported for incidence. morbidity, and mortality for essential hypertension. We examined racial differences for markers of target organ damage in black and white hypertensives. Systemic hemodynamics (cardiac output [CO], intraarterial pressure, total peripheral resistance [TPR], echocardiographic parameters of left ventricular hypertrophy (left ventricular mass [LVM], relative wall thickness [RWT], and renal hemodynamics (renal blood flow [RBF), renal vascular resistance [RVR])) were determined in 283 hypertensive subjects (204 whites, 79 blacks). Matched pairs were formed by computer analysis with the following matching criteria: same sex, MAP ≤ Δ 5 mmHg, weight ≤ Δ 15 kg, age ≤ Δ 10 yrs. 42 matched pairs were identified for subsequent comparative analysis. Mean arterial blood pressure was 106.1 mmHg versus 106.64 mmHg, respectively. white hypertensives black hypertensives p CO (1/min) 6.0 ± 1.2 5.9 ± 1.2 n.s. TPR (U) 1.83 ± 4.5 18.5 ± 4.4 n.s. LVM(g) 217 ± 70 225 ± 71 n.s RWT 0.4 ± 0.1 0.4 ± 0.1 n.s. RBF (ml/min) 1052 ± 287 1067 ± 307 n.s. RVR (U) 106 ± 29 119 ± 41 n.s. Data are expressed as mean ± 1 SD After adjustment for level of arterial blood pressure, age, sex and weight, no significant racial differences in indices of target organ damage can be observed between black and white hypertensives.