Abstract
A randomised double blind study of 2 PAA solutions given to 64 neonates showed better survival and more normal plasma aminograms in the group receiving M (McIntosh 8 Mitchell 1990). 23 on M and 25 on V completed the study. At 3 years (range 2.5-3.5) 32 survivors were identified (19 M, 13 V). 17 M and 10 V were psychometrically tested without knowledge of the original course of illness or aminoacid regimen. (2 M and 2 V could not be obtained for testing and 1 V infant was untestable).2 of 17 M and 4 of 10 V children had below average cognitive ability. Overall 15 of 21 who received 5 days of preparation M and were tested had average or above cognitive ability compared to 6 of 23 who received preparation V and were tested (OR = 7.08, 95% CI = 1.59-33.13, P 0.01). Assuming original double blind randomisation of the groups, the outcome following the use of PAA solution M is superior to V.McIntosh N & Mitchell V, Arch Dis Child 1990; 65: 692-699.
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