Abstract
The study of the role of oncosuppressors in tumor transformations and in the death of tumor cells is an important aspect in many areas of biochemistry. One of the most well-known tumor suppressors is the p53 protein. The function of the p53 protein is to regulate the expression of genes whose products lead to cell cycle arrest and apoptosis. Many types of cancer are associated with inactivation of the tumor suppressor p53 as a result of mutation. The p53Y220C oncogenic mutation it creates an extended surface pocket in the DNA-binding domain.
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