773 PROSPECTIVE EVALUATION OF THE EARLY IMPACT OF THE LHRH ANALOGUES, IN THE TREATMENT OF PROSTATE CANCER, IN SEXUAL, PSYCHO-COGNITIVE, EMOTIONAL AND QUALITY OF LIFE PARAMETERS

Abstract

You have accessJournal of UrologyProstate Cancer: Advanced II1 Apr 2012773 PROSPECTIVE EVALUATION OF THE EARLY IMPACT OF THE LHRH ANALOGUES, IN THE TREATMENT OF PROSTATE CANCER, IN SEXUAL, PSYCHO-COGNITIVE, EMOTIONAL AND QUALITY OF LIFE PARAMETERS Alfredo Rodríguez, Javier Romero, Borja Garcia, Felix Guerrero, Angeles Cabeza, Maria Clavel, Beatriz Mugica, Eduardo Lanzos, and Rafael Diaz Alfredo RodríguezAlfredo Rodríguez Madrid, Spain More articles by this author , Javier RomeroJavier Romero Madrid, Spain More articles by this author , Borja GarciaBorja Garcia Madrid, Spain More articles by this author , Felix GuerreroFelix Guerrero Madrid, Spain More articles by this author , Angeles CabezaAngeles Cabeza Madrid, Spain More articles by this author , Maria ClavelMaria Clavel Madrid, Spain More articles by this author , Beatriz MugicaBeatriz Mugica Madrid, Spain More articles by this author , Eduardo LanzosEduardo Lanzos Madrid, Spain More articles by this author , and Rafael DiazRafael Diaz Madrid, Spain More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.860AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The castration with LHRH agonists (LHRHa) in the control of the prostate cancer (PC) is associated with a wide spectrum of body, metabolic, sexual and psycho-cognitive alterations. Nowadays it is still not well documented the time to develop and the severity of these changes. We are developing a study to evaluate which, the moment and the severity of appearance of these modifications. METHODS Unique institution prospective and descriptive study. IRB approval. Study population: High risk PC patients submitted to radiotherapy and long period adjuvant hormonotherapy with LHRHa. Included consecutively from September 2009 to January 2011. To evaluate the symptoms 5 validated questionnaires were administered: baseline and 3, 6, 12, 24 and 36 months after therapy start: 1. International Index Erectile Function (IIEF): sexual modifications; 2. Aging Males' Symptoms Scale (AMSS): androgenic deficit, 3. Minimental test (MM): Cognitive area, 4. Short Form Health Survey SF-12 : Quality of life; 5. Beck Depression Inventory (BDI) Mental status and depression. Data were analyzed with the Wilcoxon test with a statistical significance p value < 0,05. RESULTS 61 patients were available at 6 months at least evaluation. The IIEF shows: a dramatic decrease since the first evaluation (p<0,05). AMSS test shows a progressive worsening (28, 32, 33 points at 6 months) (p <0,05). The MM test (cognitive area) does not demonstrate any significant alteration. SF-12 test (mental health area) shows a deterioration after 6 months (p=0,03). The rest of evaluated parameters do not present modifications. A deterioration in the BDI test (depresion area) is observed from the baseline (3,5 points) to the 3 months evaluation (4,9 points) (p=0,08), that consolidates at the 6 months (5,8 points) (p=0,030). CONCLUSIONS Treatment with LHRHa shows from initial stages (3 months) deleterious effects, fundamentally in the sexual sphere. At 6 months a slight deterioration of the mental status appears, which is confirmed in the paragraph of mental health when we evaluate the quality of life. Neither the cognitive capacity, nor the rest of quality parameters of global life seem to be diminished at this early period of time. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e315-e316 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alfredo Rodríguez Madrid, Spain More articles by this author Javier Romero Madrid, Spain More articles by this author Borja Garcia Madrid, Spain More articles by this author Felix Guerrero Madrid, Spain More articles by this author Angeles Cabeza Madrid, Spain More articles by this author Maria Clavel Madrid, Spain More articles by this author Beatriz Mugica Madrid, Spain More articles by this author Eduardo Lanzos Madrid, Spain More articles by this author Rafael Diaz Madrid, Spain More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...