Abstract
Seventy patients from five centres were identified as having primary cutaneous lymphoma (excluding mycosis fungoides and Sezary syndrome). All histology was reviewed and graded according to the Working Formulation (WF) or updated Kiel classification. Full staging was performed to exclude extracutaneous disease at presentation. The median age was 58 (91–25); male: female ratio 1.7:1; 46 patients presented with solitary lesions (9 with satellite lesions), in 10 patients the distribution was generalised. There were 11 low grade lymphomas (WF A-C)—9 B-cell, 2 T-cell and 59 high grade tumours (WF E-H, LCA,)—33 B-cell, 10 T-cell, 16 immunohistochemistries were non-evaluable. The complete response (CR) rate to first treatment was 80% (56/70) and the CR rate for soli tary lesions treated with radiotherapy was 92% (23/25). The lymphoma specific progression free survival was 75% at 1 year, 51% at 5 years with a median of 107 months. Median follow up was 47 months. Twenty-five patients (36%) had at least one cutaneous relapse and 8 (11%) developed an extracutaneous relapse. The risk factors for relapse were >5 lesions (P 60 (P 5 lesions (P
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