Abstract
Successful nerve regeneration requires not only that neurons reconstruct new axons distal to the site of injury, but also those growing axons must navigate through the neuropil to make appropriate synaptic connections with target cells. While this is an imposing task for the thousands of axons that may occupy a regenerating nerve in the peripheral nervous system or a tract in the central nervous system, the billions of neurons in the developing brain must accomplish similar tasks making connections that number in the trillions. How do neurons do this?
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