Abstract
The human skin is a complex organ to bioengineer because of its cellular diversity and regional properties. Recreating this complexity in vitro has substantial implications on personalized skin replacement therapy and drug screening. The current paradigm in reconstructing 3D skin generates planar patches with open boundaries on all sides and disregards the fact that human skin is, in fact, a fully-enclosed organ with complex geometries. In this study, we challenge this paradigm by reimagining 3D skin constructs as fully-enclosed continuous tissues which can be seamlessly transplanted as a biological clothing, e.g., skin gloves, on any part of the body.
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