763: Repeated measures of PlGF, PP13 and ADAM12 at first and second trimester for preeclampsia screening

Abstract

infants who were SGA ( 10th percentile). Multiple pregnancy had the most significant impact on all above biomarkers levels compared to other adjustment variables in the unaffected group. PlGF seems to be the best biomarker predictor of PE, with V1 and V2 median MoMs in women with subsequent PE of 0.70 and 0.44 in singleton pregnancies, and 0.34 and 0.22 in multiple pregnancies, respectively (Table). At a 10% false-positive rate, Sft1/PlGF ratio and PlGF alone at V1 had respectively a 25% and 21% sensitivity for predicting subsequent PE in singleton pregnancies, versus 40% and 60% in multiple pregnancies. At V2 Sft1/ PlGF ratio and PlGF alone detected 33% and 39% of PE cases in singleton pregnancies versus 60% and 40% in multiple pregnancies, respectively. With regard to SGA, PlGF alone was the best predictor, with a 31% sensitivity in singleton pregnancies at 12-18 weeks at V1 and 27% in multiple pregnancies, again at a 10% false positive rate. CONCLUSION: Maternal plasma PlGF level and PlGF/sFlt-1 ratio were strong predictors of subsequent PE and SGA as early as 12-18 weeks in particularly in multiple pregnancies.