Abstract
Skin wound healing results in hemostasis, inflammation, proliferation, and remodeling. The early phases require the recruitment of several immune cells from the blood. However, the role of these cells is not well defined. In addition to monocytes-derived macrophages, known to regulate the outcome of wound healing, resident macrophages in the injured skin may play a distinct role in the healing process. The aim was to develop a 3D autologous skin model containing immune and endothelial cells, to investigate their contribution during wound healing.
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