76: Lentiviral-mediated overexpression of stromal derived growth factor-1Α improves impaired diabetic wound healing

Abstract

Background: Chronic wound related morbidity continues to be a major clinical problem and novel therapeutic approaches are needed. Stromal derived growth factor -1α (SDF-1α) is a chemokine important in the recruitment of progenitor cells and more recently has also been shown to be down-regulated in response to inflammation in dermal wound healing. Previous work from our laboratory has demonstrated that improved cutaneous wound healing with the local application of fetal murine MSC in diabetic mice was due in part to increased production of SDF-1α.