Abstract
Glucose utilisation and oxidation were measured at day 8 in 19 stable VLBW infants (b.w. 1389±300g, g.a. 32±2wks) receiving cont. TPN of 76±4 kcal/kg/d. Glucose utilisation was measured by ind. calorimetry during 8 hrs and glucose oxidation by measurement of 13CO2/CO2 ratio in breath by IRMS during primed constant infusion of U-13C glucose (2.7 μmol/kg/h). Results ± S.D.:In 5 patients the rate of glucose appearance (Ra) in plasma was quantified from the enrichment of 13C glucose (m+6) by GCMS analysis. The Ra was 10.8±9.6% above glucose intake representing endog. gluc.prod. and recycling. Therefore the max. plasma glucose oxidation is 5.85±1.42 mg/kg/min. We conclude that during this feeding regimen: 1) 66±13% of the Ra is directly oxidized representing 75±18% of the glucose intake; 2) endogenous glucose production and glucose recycling is low; 3) glucose utilisation is close to glucose oxidation indicating limited lipogenesis.
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