754: High-normal liver and renal function tests are associated with small-for-gestational age (SGA) newborns in preeclamptic patients

Abstract

are associated with small-for-gestational age (SGA) newborns in preeclamptic patients Frances Hsieh, Adam C Urato Tufts Medical Center, Obstetrics and Gynecology, Boston, MA, Tufts Medical Center, Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Boston, MA OBJECTIVE: Preeclamptic patients with abnormal liver and renal function tests are considered to have a more severe form of the disease. This study investigates whether preeclamptic patients with high-normal laboratory values also have evidence of more severe disease. STUDY DESIGN: A retrospective cohort study was performed on consecutive patients delivered at a single tertiary care center in Boston with a diagnosis of preeclampsia from Dec 2006 to July 2010. Maternal / neonatal demographic data were abstracted from the medical records, including liver and renal function laboratory data (BUN, Creatinine, AST, ALT, LDH) and birth weight. Subjects were excluded if data were incomplete. SGA was defined as birth weight 13 mg/dl, Creatinine 1.0 mg/dl, AST 42 IU/L, ALT 40 IU/L, LDH 433 IU/L). RESULTS: 379 patients were included in the final analysis. 111 patients had an SGA newborn. Table 1 demonstrates that preeclamptic patients with both abnormal and high-normal liver and renal function tests were significantly more likely to have an SGA newborn compared with preeclamptic patients with low-normal lab values. CONCLUSION: Preeclamptic patients with high-normal laboratory values were significantly more likely to deliver an SGA newborn compared with preeclamptic patients with low-normal values. These findings suggest that preeclamptic patients with high-normal chemistry lab values may have a disease pathophysiology that more closely resembles that of patients with abnormal values than those with lownormal values.