753 Preferential recruitment of immature neutrophils enables robust skin regeneration

Abstract

After severe injury, adult mammalian wound healing occurs by formation of fibrotic scar and loss of skin appendages resulting in permanent functional impairment. In mice, severe skin injuries exhibit partial regeneration, including formation of new hair follicles (HFs) in the center of the wound, whereas the periphery remains fibrotic. We previously showed that fibroblasts residing within the regenerative zone exhibit activation of unique transcriptional programs reminiscent of early skin development (Abassi et al, Cell Stem Cell).