753 A COMPARISON OF INTRACAVERNOSAL AND INTRASPONGIOSAL PRESSURE RECORDING USING THE TELEMETRIC DEVICE IN CONSCIOUS RATS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011753 A COMPARISON OF INTRACAVERNOSAL AND INTRASPONGIOSAL PRESSURE RECORDING USING THE TELEMETRIC DEVICE IN CONSCIOUS RATS Jun-Ho Lee, Sung Won Lee, Mikyeong Ko, Mee Ree Chae, Hyunjung Kim, Deok Hyun Han, Woo Jung Kim, Sung Chul Kam, Jong Kwan Park, Ju-Hong Jeon, and Insuk So Jun-Ho LeeJun-Ho Lee Seoul, Korea, Republic of More articles by this author , Sung Won LeeSung Won Lee Seoul, Korea, Republic of More articles by this author , Mikyeong KoMikyeong Ko Seoul, Korea, Republic of More articles by this author , Mee Ree ChaeMee Ree Chae Seoul, Korea, Republic of More articles by this author , Hyunjung KimHyunjung Kim Seoul, Korea, Republic of More articles by this author , Deok Hyun HanDeok Hyun Han Seoul, Korea, Republic of More articles by this author , Woo Jung KimWoo Jung Kim Seoul, Korea, Republic of More articles by this author , Sung Chul KamSung Chul Kam Jinju, Korea, Republic of More articles by this author , Jong Kwan ParkJong Kwan Park Jeonju, Korea, Republic of More articles by this author , Ju-Hong JeonJu-Hong Jeon Seoul, Korea, Republic of More articles by this author , and Insuk SoInsuk So Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1778AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The current widely used method to quantify erectile function is intracavernosal pressure (ICP) assessment in anesthetized animals using cavernous nerve stimulation model which has obviously the drawbacks of the animal being unconscious and assessment being done in a single time point. Telemetric monitoring of ICP and intraspongiosal pressure (ISP) in freely moving rats was introduced to evaluate erectile function under physiological conditions. But there is no report about which one is more suitable for evaluating erection. In the present study, we compared ICP with ISP in normal rat (n=6). METHODS Adult rats (Sprague-Dawley; 18 weeks aged) were implanted in the corpus cavernosum and corpus spongiosum with a pressure sensor (model C40; Data Sciences, St. Paul, MN) which permitted telemetric monitoring of cavernosal pressure in freely moving animals following subcutaneous injection of a single dose of apomorphine (100μg/kg). First peak after injection(s), number of events, duration(s), maxinum ICP/ISP (ICPMax/ISPMax), area under the curve (AUC), sum area under the curve (sum AUC) recorded during apomorphine erection tests. Also, sexual events were visually identified and video recorded. RESULTS An erectile event was defined as an episode, which begins by a gradual increase in the cavernosal pressure and followed by multiple supeimposed very brief surges in the pressure, and ends by gradual decline of the pressure to reach baseline levels. As for the ICP recording, Number of penile erectile events for 30 min. was 2.2±0.3, and it corresponded to visually detected penile erections. Latency for the first penile erection event was 307.1±49.8 sec. Mean ICPMax, mean AUC, and mean sum AUC were 193.6±66.4 mmHg, 1401.4±301.3 mmHg·s, and 2895.7±827.2 mmHg·s, respectively. But, ISP recording showed no typical pressure change as shown in ICP recording. There were only 3.0±1.0 events that include simple 10 peaks without baseline pressure increase (>450mmHg*s), and it was less than 5 sec. And it was difficult to analysis because its artifact. CONCLUSIONS ICP recording by using telemetry device provided a consistent and accurate data during erectile events, while ISP recording was difficult to identify changes of intrapenile pressure due to its artifact. Further work is required to establish a standard analysis ISP recording method for more effective evaluation of erectile activity during telemetry recording. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e303 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jun-Ho Lee Seoul, Korea, Republic of More articles by this author Sung Won Lee Seoul, Korea, Republic of More articles by this author Mikyeong Ko Seoul, Korea, Republic of More articles by this author Mee Ree Chae Seoul, Korea, Republic of More articles by this author Hyunjung Kim Seoul, Korea, Republic of More articles by this author Deok Hyun Han Seoul, Korea, Republic of More articles by this author Woo Jung Kim Seoul, Korea, Republic of More articles by this author Sung Chul Kam Jinju, Korea, Republic of More articles by this author Jong Kwan Park Jeonju, Korea, Republic of More articles by this author Ju-Hong Jeon Seoul, Korea, Republic of More articles by this author Insuk So Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...