751 OPTIMAL FOLLOW-UP ARRANGEMENTS FOR INVASIVE SQUAMOUS CARCINOMA OF THE PENIS

Abstract

You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease II1 Apr 2012751 OPTIMAL FOLLOW-UP ARRANGEMENTS FOR INVASIVE SQUAMOUS CARCINOMA OF THE PENIS Hussain M. Alnajjar, Matthew J.A. Perry, Rowland W. Rees, Catherine M. Corbishley, and Nick A. Watkin Hussain M. AlnajjarHussain M. Alnajjar London, United Kingdom More articles by this author , Matthew J.A. PerryMatthew J.A. Perry London, United Kingdom More articles by this author , Rowland W. ReesRowland W. Rees London, United Kingdom More articles by this author , Catherine M. CorbishleyCatherine M. Corbishley London, United Kingdom More articles by this author , and Nick A. WatkinNick A. Watkin London, United Kingdom More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.837AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Follow up arrangements for squamous cell carcinoma of the penis (SCCp) are generally based on small retrospective studies. EAU guidelines recommend close follow up for 5 years in all patients. We aimed to provide more stratified follow-up arrangements based on risk of recurrence derived from a large contemporary series of patients treated at a single supra-network centre. METHODS Prospective review of all newly diagnosed primary SCCp treated surgically from 2000-2011. Tumour recurrence was defined as local (penile), regional (inguinal), distant recurrence (pelvic nodes/metastatic) at least 3 months after definitive primary surgery. Inclusion criteria: all patients regardless of tumour grade who had penile surgery leaving no residual glanular epithelium, with clear local margins, fully staged regional nodes and pathological N stage pN0/pN1. RESULTS 228 of 420 (54%) newly diagnosed SCCp patients met the inclusion criteria. All were fully staged with sentinel node biopsy or prophylactic node dissection and confirmed to have N0/N1 nodal status. In the first 12 months surveillance there were 5 local, 2 regional and 2 distant recurrences (3.9%). 2/228 developed late local recurrence (17 and 29 months). Both had G1T1 lesions locally excised. No patient had nodal or metastatic disease after 12 months. The remainder of the patients remained disease free at a mean of 44 months follow up. CONCLUSIONS For patients who have penile surgery which removes all glanular epithelium and have been staged N0 or N1, there are few recurrences overall, and the majority occur within 12 months of primary treatment. We therefore recommend a maximum follow up of one disease-free year for this sub-group who represent a significant proportion (54%) of all patients with invasive cancer. This will reduce the burden of unproductive surveillance. All other patients should continue to be followed up five years. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e307 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hussain M. Alnajjar London, United Kingdom More articles by this author Matthew J.A. Perry London, United Kingdom More articles by this author Rowland W. Rees London, United Kingdom More articles by this author Catherine M. Corbishley London, United Kingdom More articles by this author Nick A. Watkin London, United Kingdom More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...