Abstract
Minocycline is a second-generation tetracycline drug that is widely used to treat a variety of infectious and inflammatory diseases such as acne vulgaris. The effects of minocycline on acne vulgaris have been primarily attributed to its anti-inflammatory effect; however, the relevance between its sebum-regulating effect and epigenetic regulation in human sebaceous glands remains unexplored. Here, we identified a potential underlying epigenetic mechanism of the sebum inhibitory effect of minocycline in human SZ95 sebocytes.
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