Abstract
Testing of intestinal permeability appears to be an objective means of diagnosing food allergy. Permeability was measured by the differential absorption of mannitol and lactulose in 17 healthy children aged 1-38 months, and 11 aged 2-46 months, with milk allergy agreed on clinical history. After an oral load containing 2.5 g of mannitol and 2.5 g of lactulose, urine concentrations were determined by gas-liquid chromatography. Statistical analysis was performed using Mann and Whitney's or Wilcoxon's T test. In children with cow's milk allergy, lactulose/mannitol excretion ratios were 1) before milk challenge (mean 0.056 ± sd 0.040) significantly higher (p < 0.01) than in controls (0.017 ± 0.018), 2) after challenge (0.239 ± 0.303) significantly higher (p < 0.05) than before; 3) when the challenge was preceeded by 100 mg of oral sodium cromoglycate the permeability ratios (0.050 ± 0.033)were close to the basal ratios before challenge. This triple evaluation of intestinal permeability could be useful for the diagnosis of cow's milk allergy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
