Abstract
We present two models of the Red Blood Cell cytoskeleton, a soft network of non-linear elastic fibres, in response to deformation by Atomic Force Microscope: a 3D node network simulated by incremental step equilibration, and a theoretical relation based on geometric considerations. Employing both to calculate the equivalent AFM cantilever force as a function of cell strain, the methods are found to give good agreement with experimental data and illustrate an important role of structural defects in load distribution.
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