748 - Expression and Clinical Significance of NPRA in Esophageal Squamous Cell Carcinoma

Abstract

ABSTRACT Background and objective Esophageal cancer is a main reason of cancer related mortality, and the tumer targeted therapy is a new and effective treatment. NPRA (natriuretic peptide receptor A), as a new oncogene, that promotes tumorigenesis in several cancer types, might represent a novel therapeutic target in esophageal cancer. In this study we suggested that the expression and clinical significance of NPRA in esophageal squamous cell carcinoma (ESCC). Methods The expression of NPRA in 45 cases of ESCC tissues, 40 cases of adjacent tissues, 30 positive Lymph node tissues and 24 negative Lymph node tissues were assessed by SP immunohistochemical method. No patients received preoperative chemotherapy, radiation therapy, and immune therapy and all of patients were confirmed for ESCC by pathologist at Department of Thoracic Oncosurgery, the First Affiliated Hospital of Xi,an Jiaotong University. Results In esophageal squamous cells, the expression of NPRA was strongly detected in cytoplasm, while undetectable or very weak in nuclear. The positive rates of NPRA in the cancer tissues was 71.1%, while that in the adjacent tissues group was 17.5%, and showed 63.32% and 24.3% in the positive Lymph node tissues and negative Lymph node tissues respectively, there was a significant difference between the two groups ( P>0.05). Clinicopathological analyses revealed that increased cytoplasmic NPRA expression correlated with differentiation and TNM stage, while showed no statistically significant among the association of age, gender, and lymph node metastasis. Conclusion Our findings demonstrate that the NPRA has high expression in ESCC tissues, and the positive rate is closely correlated with the differentiation and TNM stage, and suggest that NPRA represents a potential therapeutic target. Disclosure All authors have declared no conflicts of interest.