Abstract
Selection sweeps have been identified in indigenous sheep breeds using the hapFLK approach. Five indigenous fat-tailed sheep breeds, the Karakul (70), Damara (35), Pedi (30), Zulu (30) and Namaqua Afrikaner (48), one composite fat-tailed breed, the Meatmaster (20), a commercial meat breed, the Dorper (46) and one exotic sheep breed, Merino (98) were genotyped using the 50K Ovine SNP beadchip. Thirteen regions spanning 11 chromosomes were under selection across the breeds. Putative candidate genes associated with the regions under selection involved immune response (BPIFC, CLDN12, CLDN14, TRL4), ultraviolet exposure and thermoregulation (KCNJ5, FZD1, ACADSB, SCNA11), energy metabolism (MYH9) and meat production (PDEZA, UTRN). These results confirm natural selection for adaptive traits such as immunity, heat tolerance and meat production in indigenous sheep breeds.
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