Abstract
Retinoic acid-related Orphan Receptor gamma (RORγ) is a transcription factor that controls the differentiation and maintenance of Th17, Tc17, γδ T and innate lymphoid cells. Abundance of Th17+ cells and high levels of the Th17 cytokine IL-17 are associated with good clinical prognosis and outcomes in some cancers. RORγ is a master controller which tightly regulate the expression of genes, including Th17 cytokines, that are critical in enhancing antitumor immunity and inhibiting immune suppression.
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