Abstract
In previous studies, we detected high levels of expression of the cardiovascular transcription factor, Nkx2-5 in trophoblast cells of placenta from cases of early onset and severe pre-eclampsia (EOSPE). These elevations were highly correlated with increased expression of the PE marker sFlt-1, and the expression of an Nkx2-5 target gene, the mRNA splicing factor, Sam68, which potentially mediates sFlt-1 production in Caucasian, but not African American women. These findings raised the hypothesis that ectopic expression of Nkx2-5 in placental trophoblast might contribute to EOSPE severity through increased placental sFlt-1 production.
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