#74 PROGNOSTIC ROLE OF EOSINOPENIA IN CHILDHOOD SEPSIS

Abstract

Abstract Background Sepsis constitutes one of the most common causes of morbidity and mortality in children. To improve the survival of childhood sepsis, while reducing the risk of antimicrobial resistance, it is obligatory to perform disease risk stratification and risk-adapted antimicrobial treatment. Recently, procalcitonin and C-reactive protein (CRP) are widely used as markers in tertiary health facilities. Due to financial constraints, however, it is not possible to determine procalcitonin and CRP levels in the majority of health facilities in developing countries. A number of studies described that the absolute number of eosinophils decreases in the acute phase of bacterial infection. Method This medical record-based cross-sectional study involved children 1 – 18 years of age with the clinical suspicion of sepsis, who were admitted to Dr. Sardjito General Hospital during the period of 2017 – 2021. Children, who received immunosuppressive agents and had no complete medical record data, were excluded from this study. Results A total of 149 children were included in which 7.4% (11) cases with eosinopenia and 52.3% (78) cases with sepsis. Septic patients with eosinopenia had a mortality rate 33.3% less than patients without eosinopenia at 43.2%. There was no significant difference, p= 0.731. This means that there was no effect of eosinopenia on mortality. Out of 78 proven sepsis cases with microbial culture 7.69% (6) with eosinopenia and 94.73% without eosinopenia. There was not a significant difference (p = 0.880) between eosinopenia and sepsis. Conclusion Eosinopenia cannot be used to prognostic mortality childhood sepsis.