74: Incidence and Outcome of De-Novo Malignancy after Cardiac Transplantation – 20 Years Experience of a Single Center

Abstract

measurement of renal function, which is usually assessed by measuring the glomerular filtration rate (GFR). The most commonly used marker for GFR is 24hr-creatinine clearance (24hr-Ccr). Serum creatinine level is widely used for evaluation of renal function, however, muscle volume and its wasting affect data. Serum concentrations of the low-molecular-weight proteins, cystatin-C and beta 2-microglobulin (B2MG) may afford useful markers to determine a reduced GFR. Methods and Materials: Serum creatinine, cystatin-C, B2MG and 24hr-Ccr were measured in 28 adult Japanese heart transplant recipients (19 to 58 years old, 10 females) who had been under care at least 2 years after transplantation. Results: Serum cystatin-C and B2MG negatively correlated with 24hr-Ccr (r .803, P .0001 and r .687, P .0001, respectively), and correlated with serum creatinine (r .738, P .0001 and r .593, P 0.0009, respectively). By receiver operating characteristic (ROC) analysis, both cystatin-C and B2MG showed 85.7% of sensitivity and 78.6% of specificity with using a cut off value of 70 ml/min of 24hr-Ccr. Conclusions: Serum cystatin-C or B2MG would be a better GFR marker than the widely used creatinine to detect renal dysfunction after heart transplantation.