Abstract
Adeno-associated virus (AAV) vectors hold the potential to treat a variety of inherited and acquired human diseases. One of the confounding issues regarding the use of AAV in humans is the cellular immune response to the virus vector. While the ability of humoral immunity to interfere with AAV transduction is well-established, the ability of cellular immunity targeting the vector to ablate AAV transduction has only recently been identified. Our laboratory previously described the use of adenovirus expressing AAV capsid as a means to invoke a cellular immune response towards AAV in a mouse model system.
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