Abstract
Telomere attrition, a biological marker of aging, has been demonstrated in the cardiac muscle and leukocytes of advanced heart failure (AHF) patients and may play a role in myocardial demise. AHF therapies such as a left ventricular assist device (LVAD) unloads the left ventricle and can lead to improved myocardial function. Its effect on telomere integrity has not been studied. We hypothesized that telomere length (TL) can be used as a molecular indicator of effective treatment with a LVAD by measuring leukocyte and cardiac muscle TL during LVAD therapy.
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Schedule a callMore From: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
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