Abstract
The normal postprandial response in newborn piglets is characterized by increased gastrointestinal(GI)blood flow (QGI), O2. delivery (DO2GI), O2 extraction (O2 ExGI) and O2, consumption (VO2GI). Hypoxemia may modify these physiological changes. To test this hypothesis, nine 2-4 day old piglets were made hypoxemic (PaO2: 26-28 torr for 45 min.)& fed with 30ml/kg of pig milk (Group I). 6 piglets were made hypoxemic but not fed (Group II) and 4 were fed but not hypoxemic (Group III). QGI1, (ml·min · 100g−1, microsphere method), DO2 GI(ml O2 · min · 100g−), O2ExGI(%), and VO2GI (ml O2·min−1 · 100g−1) during Baseline (B), and hypoxemic (H) and/or fed (F, 30-min postprandial) periods were: (M±SEM) The normal increase in VO2GI to meet the postprandial metabolic demands was not observed in Group I, because the increase in O2ExGI produced by feeding did not fully compensate for the decrease in QGI and DO2GI produced by hypoxemia. We conclude that hypoxemia blunts the normal postprandial hyperemia and the extent to which blunted GIO2 uptake satisfies the postprandial O2, demand remains to be determined.
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