736-P: Two Years Moderate Resistance Training Prevents Type 2 Diabetes but Does Not Reduce Cardiovascular Risk for Patients with Prediabetes

Abstract

Resistance training can decrease blood glucose, reduce fat volume and increase muscle mass, but whether long term resistance training can prevent type 2 diabetes and reduce cardiovascular risk or not remains unclear. 248 prediabetes patients enrolled in this multicentered RCT study were randomized in to 3 groups: resistance training (RT, n=82), aerobic training (AT, n=83), and control group (n=83). The participants in RT and AT groups did moderate RT or AT 3 times a week (150minutes/week) with supervision in 3 research centers for 2 years. Compared to the control group, participants in both RT group and AT group experienced a significant reduction in A1c at month 6, 12 and 24. After adjusted for age, sex, BMI, and statin use, Resistance training and aerobic training reduced type 2 diabetes risk by 58.2% (p=0.028) and 73.2% (p=0.004), respectively, but neither AT nor RT reduced cardiovascular risk (Framingham Score). In terms of remission to normal glucose tolerance (NGT), RT and AT increased the RR by 7.84 (p=0.008) and 6.68 (p=0.016), respectively. The results of this study demonstrated that 2 years moderate resistance training has comparable effects on preventing type 2 diabetes and reversing to NGT for patients with prediabetes. Disclosure Q. Lou: None.