734MO Deep sequencing of the T-cell receptor reveals common and reproducible CD8 T-cell receptor signatures of response to checkpoint immunotherapy

Abstract

Immune checkpoint blockade (ICB) has revolutionized the treatment of metastatic melanoma (MM). However, robust biomarkers of response and the identity of key antigenic targets remains lacking. We have previously demonstrated the importance of large peripheral CD8+ T cell clones in the ICB response; these clones being more cytotoxic and especially sensitive to ICB. However, identifying key groups of T cells based on their T cell receptor (TCR) usage has remained elusive.