732 OXIDIZED-LDL-CHOLESTEROL EVALUATIONS IS USEFUL PARAMETER TO ESTIMATE ORGAN DAMAGE IN THE EARLY STAGE OF HYPERTENSION - SUB-ANALYSIS WITH ESTIMATED GFR - EIICHI GESHI. INTERNAL MEDICINE, SHOWA UNIVERSITY, YOKOHAMA, JAPAN

Abstract

Objective: Oxidized-LDL-cholesterol has been considered as the upper stream of pathogenesis for atherosclerosis and following cardiovascular complications. Recently malondialdehyde-LDL (MDA-LDL) has been able to measure as oxidized-LDL and usefulness of MDA-LDL to estimate cardiovascular events. On the other hand, chronic kidney disease (CKD) is evaluated as a risk for cardiovascular damages. We evaluated MDA-LDL level in health-examination subjects with/without hypertension (HT) with sub-analyzed according to the eGFR. Design and method: In the subject of health-examination without any cardiovascular events (n = 283, (M: 135, F: 148), mean ages: 45.7 yrs), after informed-consents, they were divided into with/without HT. Furthermore, they were divided into 3 groups according to eGFR (high (H) eGFR >/ = 90 mL/min/1.73m+2, 90>medium (M) eGFR >/= 60, 60>low (L) eGFR). Then in each group, serum MDA-LDA and other cardiovascular events related factors were evaluated. Results: Mean systolic BP were 118.2 mmHg in HT(-) and 146.4 mmHg in HT(+), respectively. MDA-LDL was significantly higher in hypertension (HT(+);111.7IU/L (n = 53), HT(-); 96.6, (n = 230), p < 0.01), and it was correlated with Apo-B (p < 0.01) and RLP-C (p < 0.05), significantly. Furthermore, MDA-LDL was significantly inverse correlated (p < 0.01) with eGFR and it was 133.0IU/L in L-eGFR, 104.2 in M-eGFR, and 99.0 in H-eGFR, in HT group respectively, and hsCRP and NT-PRO-BNP were also inverse collated to eGFR. These significant differences in eGFR were similar in HT(-) group. Conclusions: MDA-LDL was significantly higher in hypertension without any cardiovascular complication and it was useful parameter to estimate potential cardiovascular organ damage in the early stage of hypertension especially with CKD.