730: Should Women wait for the first menstrual period following spontaneous miscarriage before becoming pregnant again?

Abstract

To determine whether conception prior to the first menstrual period after a first trimester pregnancy loss is associated with a risk of repeat miscarriage or adverse fetal outcomes. A retrospective cohort study (n= 107 women) who had a spontaneous first-trimester miscarriage followed by a subsequent pregnancy with an IPI (interpregnancy interval) < 12 weeks. All pregnancies ended either in spontaneous, medical or surgical abortion. Pregnancy outcome was compared between women who conceived after their next menstrual period (n=57) to women who conceived prior to their next menstrual period (n=50). The primary outcome was miscarriage, and secondary outcomes were gestational age at delivery and birth weight. 1. The rate of recurrent first trimester pregnancy loss among women who conceived prior to their next menstruation was 10.4% in comparison 15.8% for women conceived after their next menstruation (p=0.604). 2. There was no difference in gestational age at delivery and birth weight between the study groups (Table). Other outcomes were also similar for both groups (Table 1). 3. Multiple logistic regression analysis confirmed that conception prior to the next menstrual period was not associated with a higher incidence of miscarriage (OR 1.74, 95% CI: 0.7-4.0, p=0.46) (Table 2). Conception shortly after a spontaneous miscarriage without waiting for the next menstrual period is not associated with adverse maternal or perinatal outcomesView Large Image Figure ViewerDownload Hi-res image Download (PPT)