Abstract
Attenuated replication-competent Edmonston lineage strains of measles virus (MV-Edm) have proven anti-tumor activity against xenograft models of human multiple myeloma, ovarian cancer and glioma. The virus is selectively oncolytic, causing extensive cell to cell fusion via CD46, which is more highly expressed on tumor cells than normal cells. However, MV-Edm retains the capacity to infect a variety of nontransformed cell types via its native receptors, CD46 and SLAM. CD46 is found on all human nucleated cells. SLAM (signaling lymphocyte activation molecule) is only expressed on activated T and B cells, dendritic cells and macrophages. Therefore, the native tropism has possibility to cause immunosupression, unwanted damage to normal tissues, and toxicity of oncolytic measles virus.
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