73 - A Rare Case of Methimazole-Induced Concomitant Cholestasis and Severe Agranulocytosis That Recovered Rapidly With High Dose Filgrastim

Abstract

Agranulocytosis and hepatotoxicity are rare, independent and idiosyncratic side effects of thionamide use with an estimated frequency of 0.2-0.5% and 0.1-0.2%, respectively. Only 4 cases (all females) of their simultaneous occurance in the same patient have been reported so far. Evidence suggests that use of granulocyte colony-stimulating factor (G-CSF) may shorten the duration of thionamide-induced neutropenia.