Abstract
Paeoniflorin (PF) is a principle active ingredient of Paeoniae Radix (PR), which has been used in Chinese traditional medicine for years, in relieving pain, especially visceral pain. The present study evaluated the antinociceptive effect of PF in neonatal maternal separation (MS) induced visceral hyperalgesia in rats, and further investigated its effective targets and the possible involvement of opioid and α2-adrenergic receptors in its antinociception process. The analgesic effect of PF was evaluated by both abdominal withdraw reflex (AWR) test and abdominal electromyography (EMG) recording in response to colorectal distension (CRD, three cycles of gradient distension: 20, 40, 60, 80 mmHg, 20 seconds duration, 2 minutes interval between distension).
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