727 Basigin controls cell cycle and the secretory phenotype of senescent epidermal keratinocytes

Abstract

Using models for pro-aging redox stress and replicative senescence models for epidermal keratinocytes (KC) we identified Basigin (EMMPRIN, CD147) to be induced in KC senescence. Known receptor- and signaling function makes Basigin a prime candidate for a functional mediator of keratinocyte senescence. Basigin regulates matrix metalloproteinases (MMPs) and the cell cycle. It thus may shape an aged proteolytic microenvironment and maintain cell cycle arrest in senescent keratinocytes. Another hypothesis was that it's paracrine signaling that leads to a