Abstract
Past studies have shown decreased levels of MSAFP in women with preconceptional diabetes, leading many laboratories to use a correction factor. Type II diabetes has become more prevalent secondary to rising obesity rates and oral hypoglycemics (OHA) have become a popular alternative to insulin in these patients. It is not clear whether the routine adjustment of MSAFP will be applicable to women on OHA, or whether this historical adjustment is still warranted.
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