Abstract
This chapter reviews the development of reagents used for glycol cleavage oxidation reactions of vicinal diols and related functional groups from 1990 to 2012. The reagents are categorized into metallic and nonmetallic reagents. Among the metallic reagents, those involving lead, manganese, ruthenium, and tin elements are versatile. For nonmetallic reagents, periodinane and related compounds are new contenders for the glycol fission reactions. Periodates are still the most popular reagents for the reaction because of their stability, cost, versatility, and efficiency. The applications of glycol cleavage reactions in organic syntheses are also reviewed.
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