Abstract
Sexual dimorphism exists in human skin and in the regional distribution of fat tissues, including dermal white adipose tissue (dWAT, dermal fat), which has been recently recognized as an important deep skin layer that regulates several non-metabolic functions of the skin. However, the sexual dimorphism in dermal fat has not been fully characterized, and the underlying mechanism remains poorly understood. By analyzing the age and sex-dependent changes in dWAT and the in vitro adipogenic potential of dermal fibroblasts (dFBs), we found that male dWAT volume and the adipogenic potential of male dFBs were rapidly lost by 2 months of age, whereas female dWAT and dFBs were relatively resistant to these age-dependent changes.
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