725: A retrospective study of BACs-on-Beads (BoBs) technology for identification of chromosome abnormalities compared with QF-PCR and karyotyping in prenatal diagnosis

Abstract

sion was performed to control for confounding variables. RESULTS: 309 women had CVS performed and also had pregnancy outcomes available in our database. Absence of villi buds was associated with preterm birth (p .001) and GDM (p .005). 92.6% of samples had composite scores of 2-6. High composite score (7-9) was associated with gestational hypertension (p 0.038) and 5 minute Apgar less than 7 (p 0.032). Both high (7-9) and low (0-1) composite scores were associated with preterm delivery (p 0.002). Low composite score was associated with GDM (p 0.003). Gestational age at procedure was associated with morphology (p 0.00). The association of high or low composite morphology score with these outcomes remained significant in the logistic regression analysis. CONCLUSION: Morphologic characteristics of chorionic villi already demonstrate abnormal features in the late first trimester in some pregnancies destined for poorer obstetric outcomes. Identifying the underlying molecular etiology responsible for underor overdeveloped chorionic villi may aid in a greater understanding of the molecular mechanisms leading to these adverse pregnancy outcomes.