723-P: Effect of Low-Carbohydrate High-Fat vs. High-Carbohydrate Low-Fat Diet on HbA1c Control in Chinese Patients with Type 2 Diabetes

Abstract

Aims: To explore the effect of LCHF (C<50%; F≥35%) diet vs. HCLF (C≥50%; F<35%) diet on HbA1c control in patients with T2D in 3 Chinese diabetes hospitals. Methods: Patients were enrolled if they had been assessed by professional dietitians and had electronic medical record on a diabetes share-care management database. A total of 1017 patients were eligible for this study with 44.1% in group LCHF and 55.9% in group HCLF. Results: Compared with group HCLF (Carb 59%: Fat 28%: Pro 13%), group LCHF (41%: 44%: 15%) had higher calorie intake (1845 vs. 1691 kcal/day), higher proportions of patients exceeding calorie recommendation (69.5% vs. 52.3%) and lower baseline HbA1c levels (8.29 vs. 8.52 %). HbA1c improvements were found in both groups after diabetes share-care management with significantly lower HbA1c (7.87 vs. 7.36 %) and higher proportions of patients reaching HbA1c target (31.4% vs. 47.3%) in group HCLF. Binary logistic regression analysis showed that exceeding calorie recommendation [OR(95%CI): 0.703 (0.514∼0.961)]was a risk factor at baseline and LCHF diet was a risk factor [OR(95%CI): 0.549 (0.327∼0.924)] at follow up visit for reaching HbA1c target. Conclusions: There were higher proportions of patients reaching HbA1c target in group HCLF than in group LCHF after share-care model management. LCHF diet was associated with lower likelihoods of achieving HbA1c target. Disclosure L. An: None. D. Wang: None. X. Shi: None. C. Liu: None. K. Yeh: None. T. Lee: None. L. Ji: None.