721 Efficacy of silybum marianum extract, manganese PCA and lespedeza capitata extract on hair growth and anchorage in human dermal papilla cells

Abstract

The hair follicle (HF) undergoes cycles of growth (anagen), regression (catagen) and rest (telogen) phases. Both chronic and reactive hair loss are linked to a dysfunction of the HF cycle leading to a premature hair loss. Therefore, the use of specific active ingredients targeting the HF could improve hair loss. The aim of this study was to evaluate the efficacy of 3 active ingredients on hair growth and anchorage in dermal papilla cells isolated from human hair follicle (DPC): a new patented extract from Silybum marianum containing less than 2% silymarin (SME) and stimulating hair shaft anchorage by keratin 75 modulation (Patent WO/2021/023820), Manganese PCA (MnPCA) and a Lespedeza capitata extract (LCE) (Patent WO/2020/020791A1).