Abstract
Celiac disease (CD) is a chronic inflammatory disorder of the small intestine that is associated with certain human leukocyte antigen (HLA) antigens encoded by the DQA1 and DQB1 genes. Guidelines recommend screening patients for tissue transglutaminase (tTG)–IgA autoantibodies (tTG-IgA), yet this is complicated by the fact that IgA deficiency occurs at a higher frequency in CD patients. Although tTG-IgG and anti-deamidated gliadin (DGL)-IgG testing is available, these show decreased sensitivity and specificity in comparison to the IgA isotypes. In addition, …
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