72. Cancer of oropharynx and nasopharynx – clinical prognostic factors analysis

Abstract

Analysis contains 110 cases of oropharyngeal and 112 cases of nasopharyngeal cancers who were treated beetwen 1990–1998 in MSC Centre of Oncology-Institute, branch Gliwice. Main part of histopatological findings in oropharyngeal area were squamous cancers, but undifferentiated type was slightly dominated than squamous in nasopharyngeal region. More than half of cases in both localisations were locally advanced [T3,T4] and similar, nearly 1/3 cases were without nodal metastases. Comparisons beetwen mean tumor volumes indicate on bigger cancer volume, when primary tumor was located in oropharyngeal area, but mean nodal volume was much higher in nasopharyngeal cancer. Kinetics of distant metastases were much higher in nasopharyngeal location of primary tumor especially in undifferentiated cases. Radiotherapy was the main type of treatment which was realised in palliative and radical schedule with conventional and unconventional fractionation scheme. Following clinical factors were underdone evaluation: T-stage and primary tumor volume, N-stage with amount and volume of nodes, conglomerates of nodes presence, M-stage, type of histological structure and treatment factors: tumor and nodal total doses and kind of fractionation. Statistical methods which were used contained: single- and multivariate analysis and logistic regression model. Conclusion „Hierarchy of importance” of the factors which were analysed and their influences on treatment results are different in both localisations.