71P Capecitabine-induced adverse events: A pharmacogenetic study beyond DPYD

Abstract

Capecitabine treatment is frequently accompanied by adverse events such as hand-foot syndrome (HFS), leading to interruption --or even discontinuation-- of treatment in approximately 26% of patients. These adverse events can be mitigated with pre-emptive dose reductions in case of single nucleotide polymorphisms (SNPs) in DPYD, encoding the main fluoropyrimidine-metabolizing enzyme dihydropyrimidine dehydrogenase. However, HFS still occurs in 53-77% of patients treated with capecitabine. In this study, we investigated if SNPs in other genes involved in capecitabine metabolism are predictive for capecitabine-induced HFS.