Abstract
Close correlation between mucosal atrophy/intestinal metaplasia (IM) and gastric cancer has been reported. Recently, etiological relation between H. pylori infection and gastric cancer has been elucidated. Aim of this study is to clarify the geographical differences of mucosal atrophy/IM and H. pylori infection in the stomach among different populations in Asia, i.e. Japanese (Tokyo) 4260 cases, Chinese (Beijing) 257 cases, Vietnamese(Ho Chi-ming) 223 cases and Thai (Chaing Mai) 437 cases. Under the endoscopic examination, 3 biopsy specimens were taken from #1 antrum, #2 upper corpus and #3 angulus regions and grading of atrophy, IM and H. pylori infection were undergone by the Sydney System. Results showed most geographical differences in biopsy specimens taken from #3 angulus region. H. pylori infection was most high in Thai population in all generation, followed by Chinese, Japanese and Vietnamese in younger generation; and Japanese, Chinese and Vietnamese in elder generation. Mucosal atrophy was most high in Japanese followed by Vietnamese, Chinese and Thai; and IM was most high in Japanese followed by Chinese, Vietnamese and Thai in all generation. In conclusion, H. pylori infection correlated with mucosal atrophy/IM in Japanese but not in Thai population. These differences of stomach mucosa may attribute to high and low incidence of gastric cancer in Japan and Thai population, respectively.
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