Abstract
Combination therapy with the PD-1 inhibitor pembro and the VEGF inhibitor lenvatinib showed activity in patients (pts) with advanced ccRCC in the phase III KEYNOTE-581/CLEAR trial. The HIF-2α inhibitor belzutifan (MK-6482) and MK-1308A, a coformulation of pembro and the CTLA-4 inhibitor quavonlimab, have each shown antitumor activity in phase I/II trials. HIF-2α or CTLA-4 inhibition with PD-1 and VEGF inhibition backbone combination may provide additional benefit as 1L treatment in ccRCC.
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