Abstract
IL-17C is a keratinocyte-derived cytokine that promotes and amplifies innate defense in various inflammatory skin diseases including psoriasis. However, little is known about the mechanisms regulating IL-17C expression or its downstream proinflammatory effects in epithelial cells that promote psoriasis inflammation. Here we identify a critical role for the transcription factor TCF4 in the negative regulation of IL17C expression. RNAseq analyses of psoriasis patient lesional skin (n=99) revealed a negative correlation (r=-0.43, p=6.4E-06) between TCF4 and IL17C, and immunohistochemistry of lesional psoriasis skin confirmed that increases in IL-17C correspond to decreases in nuclear TCF4.
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