717 LONGTERM OUTCOME FOLLOWING RADICAL PROSTATECTOMY FOR GLEASON 8-10 PROSTATIC ADENOCARCINOMA- ANALYSIS OF 75,416 PATIENTS

Abstract

You have accessJournal of UrologyProstate Cancer: Advanced (I)1 Apr 2013717 LONGTERM OUTCOME FOLLOWING RADICAL PROSTATECTOMY FOR GLEASON 8-10 PROSTATIC ADENOCARCINOMA- ANALYSIS OF 75,416 PATIENTS Naveen Pokala, Jerry Trulson, and Ravi Kiran Naveen PokalaNaveen Pokala Columbia, MO More articles by this author , Jerry TrulsonJerry Trulson Columbia, MO More articles by this author , and Ravi KiranRavi Kiran Cleveland, MO More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.276AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES This study evaluates the long term survival following radical prostatectomy (RRP) for non-metastatic Gleason 8-10 prostate adenocarcinoma. (CaP). METHODS All patients that were 75 years or less with Gleason 8-10 CaP that underwent RRP were identified form the SEER 18 database. Patients with metastatic disease, other modalities of treatment, with more than one primary cancer were excluded. Data was analyzed for demographics, stage at presentation, treatment modality and overall (OS) and cancer specific survival. (CSS). RESULTS 75, 416 patients were identified. The mean age was 61.4 years (range 26-75), 81.5%(n=61494) were white, 12.3% (9307) were Black and 6.1% (4615) belonged to other races. 46,286 (61.4%) patients also underwent Pelvic lymph node dissection (PLND) and 6167 (8.2%) patients underwent adjuvant radiation after surgery. The OS was 94%, 80%, 38% and 18% at 5-, 10-, 20 and 25-years respectively. The corresponding CSS was 94%, 88%, 68% and 64%. The OS in patients that underwent PLND was 95% and 84%. There was no significant survival difference in the CSS in patients that underwent PLND or RRP alone. The CSS was 98% and 92% in PLND and 98% and 94% at 5 and 10-years respectively in the RRP alone group. The OS in patients that received adjuvant RT was 90%, 70%, 38% and 18% respectively and the CSS was 94%, 78%, 58% and 48% at 5-, 10-, 20- and 25- years respectively. The CSS for patients that did not receive adjuvant RT was 98%, 91%, 70 and 65% at 5-, 10-, 20- and 25- years respectively. CONCLUSIONS Excellent long term survival can be achieved with RRP for G 8-10 Cap. PLND for these patients does not seem to increase survival significantly. Patients that required adjuvant radiotherapy had a significantly poorer survival when compared to patients that did not require adjuvant radiation. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e294-e295 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Naveen Pokala Columbia, MO More articles by this author Jerry Trulson Columbia, MO More articles by this author Ravi Kiran Cleveland, MO More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...